U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Txk TXK tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305311, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Txkprovided by RGD
    Official Full Name
    TXK tyrosine kinaseprovided by RGD
    Primary source
    RGD:1306481
    See related
    Ensembl:ENSRNOG00000025925 AllianceGenome:RGD:1306481
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including activation of phospholipase C activity; positive regulation of immune response; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within NK T cell differentiation. Predicted to be located in cytoplasm and nucleus. Orthologous to human TXK (TXK tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 104.8), Spleen (RPKM 80.2) and 6 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    14p11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (35817270..35873454)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (35463369..35519448)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (38029809..38085822)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 4, pseudogene 3 Neighboring gene tec protein tyrosine kinase Neighboring gene NIPA-like domain containing 1 Neighboring gene cyclic nucleotide gated channel subunit alpha 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site. Kashiwakura J, et al. Biol Pharm Bull, 2002 Jun. PMID 12081135
    2. Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes. Kashiwakura J, et al. J Exp Med, 1999 Oct 18. PMID 10523612, Free PMC Article
    3. Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription. Takeba Y, et al. J Immunol, 2002 Mar 1. PMID 11859127
    4. The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival. Felices M, et al. J Immunol, 2008 Mar 1. PMID 18292523
    5. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Schaeffer EM, et al. Science, 1999 Apr 23. PMID 10213685

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within NK T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type II interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tyrosine-protein kinase TXK
    NP_001019426.1
    XP_038947821.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024255.1 → NP_001019426.1  tyrosine-protein kinase TXK

      See identical proteins and their annotated locations for NP_001019426.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095847
      UniProtKB/TrEMBL
      A0A8I5Y280, Q501W1
      Related
      ENSRNOP00000030643.3, ENSRNOT00000035623.5
      Conserved Domains (4) summary
      cd10398
      Location:142 → 247
      SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
      cd11907
      Location:84 → 138
      SH3_TXK; Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)
      pfam07714
      Location:270 → 519
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:265 → 520
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      35817270..35873454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091893.2 → XP_038947821.1  tyrosine-protein kinase TXK isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y280
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous